NAD+ Benefits: A New Era For Anti-Aging

NAD+ stands for nicotinamide adenine dinucleotide and is considered part of a new era for anti-aging due to its crucial role in cellular metabolism and repair. NAD+ injections are currently offered in our office. Here are a few key reasons why NAD+ is attracting attention in the field of anti-aging:

1. Energy Production: NAD+ is essential for the function of mitochondria, the energy-producing structures in cells. Higher levels of NAD+ can enhance cellular energy production, which often declines with age.
2. DNA Repair: NAD+ is involved in repairing DNA damage. As we age, the ability of cells to repair damaged DNA diminishes, and boosting NAD+ levels can help support this repair process.
3. Sirtuin Activation: NAD+ benefits include the activation of sirtuins, a family of proteins linked to longevity and cellular health. Sirtuins play a role in regulating metabolism, inflammation, and stress responses.
4. Metabolic Regulation: NAD+ helps regulate various metabolic processes, including those related to weight and glucose metabolism. This can be beneficial for managing age-related metabolic decline.
5. Cellular Health: By supporting cellular processes and reducing oxidative stress, NAD+ supplements may help maintain healthier cells and tissues over time.

Overall, the idea is that increasing NAD+ levels could help counteract some of the biological effects of aging and improve energy, overall health and vitality. NAD+ injection is commonly given at our office with great benefit to patients, especially to boost energy, provide mental clarity, and mood. Many report better sleep as well. More research is ongoing to fully understand its long-term benefits and effectiveness.

What You Feel Like After an NAD+ Injection

When patients receive a NAD injection, they often report a rush of energy. It can feel like a weird sensation or adrenaline coming on. After an hour or so, patients often feel incredible with a big boost of quality energy. NAD+ is a coenzyme involved in energy metabolism and cellular repair. Common experiences might include:

• Increased Energy: Some people feel a boost in their energy levels and overall vitality.
• Improved Mental Clarity: Enhanced cognitive function and mental focus can occur.
• Mood Changes: You might notice changes in mood, such as feeling more balanced or uplifted.
• Detoxification Effects: Some report mild detox-like symptoms, such as fatigue or nausea, especially if their body is adjusting to the treatment.
• Better Sleep: More energy during the day allows more restful sleep at night. It is believed to help with DNA repair at night.

NAD+ benefits can vary from person to person, and it’s always good to discuss potential outcomes and side effects with a healthcare provider before undergoing treatment.

How are NAD+ Supplements Given?

It’s important to consult with a healthcare provider before starting NAD+ supplementation, especially if you have any health conditions or are taking other medications. Supplementing with NAD+ can be approached through several methods:

Oral NAD+ Supplements:

Nicotinamide Riboside (NR): A precursor to NAD+, which is often used in supplements to boost NAD+ levels.

Nicotinamide Mononucleotide (NMN): Another NAD+ precursor that is available in supplement form and believed to help increase NAD+ levels in the body. This was recently banned by the FDA and is not permitted to be sold as a supplement.

Intravenous (IV) NAD+ Therapy: NAD+ can be administered directly into the bloodstream via IV infusion. This method is used in clinical settings and is intended to provide a higher and more immediate dose of NAD+.

NAD+ Injection with Subcutaneous or Intramuscular Shot: NAD+ can be conveniently injected into the thigh or buttocks by intramuscular method or may be given in a subcutaneous injection much like GLP-1 medications are given.

NAD+ Sublingual Tablets: These are designed to dissolve under the tongue, potentially allowing for quicker absorption compared to traditional oral supplements.

NAD+ Topical Creams: Some topical products claim to increase NAD+ levels in the skin, though their efficacy is debated.

Why Does Dr. David Sinclair, A.O., Ph.D. Take NAD+ Supplements?

David Sinclair has expressed positive views about NAD+ supplements, particularly those containing NAD+ precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). Sinclair’s research has focused on the role of NAD+ in aging and cellular health, and he believes that increasing NAD+ levels can support various aspects of health and longevity.

Sinclair has discussed how NAD+ levels decline with age and how replenishing NAD+ can help mitigate some of the biological effects of aging. He cites its involvement in critical processes like DNA repair and energy metabolism. Sinclair supports the use of NAD+ precursors as a practical way to boost NAD+ levels. He personally takes these supplements and believes they could contribute to improved health and potentially extend lifespan.

Sinclair emphasizes that while the potential benefits of NAD+ supplements are promising, more research is needed to fully understand the long-term effects and benefits. He encourages continued study and exploration in this area.

NAD+ Injection for Fatigue, Anti-Aging, and Cognitive Decline

As a PA at our office, I approach the risks and benefits of NAD+ treatment for a patient’s fatigue or other health concerns with a comprehensive, evidence-based strategy. Here’s how I would proceed:

Initial Comprehensive Medical Evaluation:

We need to conduct a detailed medical history to understand your fatigue, its onset, duration, and any associated symptoms. It is important to evaluate lifestyle factors such as diet, exercise, sleep patterns, and stress levels. You will need a comprehensive physical examination to identify any signs of underlying health issues.

Laboratory Tests:

A battery of tests are usually ordered, including:
Complete blood count (CBC)
Thyroid function tests (TSH, free T3, free T4)
Adrenal function tests (cortisol levels)
Vitamin and mineral levels (B12, D, iron, magnesium)
Metabolic panel (glucose, liver and kidney function tests)
Inflammatory markers (CRP, ESR)
Hormonal panel (sex hormones, DHEA)

Specialist Referrals:
Referrals may be needed to address suspected underlying medical issues if indicated.

Evaluating NAD+ Treatment:
Once other health problems have been ruled out and you are deemed an appropriate candidate for NAD+ therapy, I would proceed with discussing the treatment:

Mechanism of Action: NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme involved in cellular energy production and mitochondrial function. It plays a key role in:

ATP Production: NAD+ is essential for the function of enzymes involved in the Krebs cycle and electron transport chain, crucial for energy production.

DNA Repair: NAD+ helps in the repair of damaged DNA, maintaining cellular health.

Sirtuin Activation: NAD+ activates sirtuins, proteins that regulate metabolic pathways and promote longevity.

Potential Benefits: For patients with fatigue, NAD+ supplementation could offer several benefits.

Improved Cellular Energy: Enhanced mitochondrial function can increase ATP production, reducing fatigue.

Enhanced Cognitive Function: NAD+ may improve mental clarity and reduce brain fog.

DNA Repair and Longevity: Regular supplementation could contribute to overall cellular health and longevity.

Potential Risks and Side Effects: While NAD+ supplements are generally considered safe, there are some potential risks and side effects. Some patients may experience nausea or gastrointestinal discomfort. Similar to niacin, high doses of NAD+ can cause flushing. Allergic reactions are rare but possible, particularly with intravenous administration. In some cases, patients may feel overstimulated or jittery.

Dosing of NAD+, Monitoring and Follow-Up: You would initially start with a lower dose of NAD+ injection and gradually increase based on patient tolerance and response. There will be follow-up appointments scheduled to monitor your response to treatment, adjust dosages, and manage any side effects.

Periodic Reevaluation: You will need periodic reevaluations, including laboratory tests, to ensure continued health and address any emerging issues.

Conclusion for NAD+ Injections

NAD+ treatment can be a valuable component in addressing fatigue, particularly when it stems from suboptimal cellular function. However, it’s crucial to perform a comprehensive medical evaluation first to rule out other health issues. Individualized treatment plans and careful monitoring are essential to maximize benefits and minimize risks.

NAD+ benefits can vary from person to person, and it’s always good to discuss potential outcomes and side effects with a healthcare provider before undergoing treatment.

Would you like more detailed information on any specific aspect of NAD+ therapy?